USB flow characteristics related to noise generation

The effects of nozzle and flap geometry on upper surface blown flow field characteristics related to noise generation were examined experimentally using static models. Flow attachment and spreading characteristics were observed using flow visualization techniques. Velocity and turbulence profiles in the trailing edge wake were measured using hot-wire anemometry, and the effects of the geometric variables on peak velocity and turbulence intensity were determined. It is shown that peak trailing edge velocity is a function of the ratio of flow length to modified hydraulic diameter

Nonlinearity without Superluminality

Quantum theory is compatible with special relativity. In particular, though measurements on entangled systems are correlated in a way that cannot be reproduced by local hidden variables, they cannot be used for superluminal signalling. As Czachor, Gisin and Polchinski pointed out, this is not true for general nonlinear modifications of the Schroedinger equation. Excluding superluminal signalling has thus been taken to rule out most nonlinear versions of quantum theory. The no superluminal signalling constraint has also been used for alternative derivations of the optimal fidelities attainable for imperfect quantum cloning and other operations. These results apply to theories satisfying the rule that their predictions for widely separated and slowly moving entangled systems can be approximated by non-relativistic equations of motion with respect to a preferred time coordinate. This paper describes a natural way in which this rule might fail to hold. In particular, it is shown that quantum readout devices which display the values of localised pure states need not allow superluminal signalling, provided that the devices display the values of the states of entangled subsystems as defined in a non-standard, but natural, way. It follows that any locally defined nonlinear evolution of pure states can be made consistent with Minkowski causality.Comment: References update

Designs on the Web: A case study of online learning for design students

The De Montfort University Electronic Campus initiative started in September 1999. Web‐based learning resources and support have been provided for over 3,000 students via a portfolio of thirty projects ranging across all levels of the university and within every faculty. This paper focuses on one aspect of this initiative: the development of online teaching and learning materials to support first‐year IT modules for students of art and design. An undergraduate module has been converted from traditional, face‐to‐face, delivery to a hybrid combination of Web‐based and studio‐based work in accordance with Laurillard's conversational framework. In the first year of use all the new material has been made available on a pilot basis to a group of 440 students in parallel with conventional lectures and seminars. All the students have had access to the online resources; some students have used them, but some have not. Data on student expectations collected prior to starting on the module are compared with student feedback gathered at the end of the module and student performance data across the two mode's of presentation are compared to establish the relative effectiveness of each approach. In addition the paper reviews the resource implications of developing, delivering and supporting online learning and discusses some of the barriers to implementation that were encountered and overcome

Entrepreneurs'' attitude towards the computer and its effect on e-business adoption

This paper presents research exploring further the concept that many SMEs do not adopt computer based technologies due to decision maker's negative attitudes towards computers generally. Importantly, by assessing the entrepreneur's belief structure, we provide quantitative evidence how SMEs, particularly micros, are affected. Earlier research that addresses technology acceptance model (TAM) suggests that TAM parameters are particularly influential factors of e-commerce adoption, as perceived by top managers of SMEs. The model we develop is tested using a sample of 655 enterprises. The information was gathered, via a telephone survey of UK SMEs, from decisions makers in the enterprise. Technically, the paper uses k-means cluster analysis to segment respondents using the TAM perceptions, ease of use, usefulness and enjoyment. Based on two determined segments we look at the differential rate of adoption of internet, and the potential adoption of new e-collaborative technologies like video conferencing and electronic whiteboards. The diffusion of internet for low IT utility (LIT) segments was considerably slower than in the high utility segment (HIT). Similarly, the anticipated adoption of e-collaboration technologies was much lower for LIT than HIT. Interestingly, we find that LIT is populated by more micro SMEs than HIT. The results we present are limited however as our sample is considerably underweight in micro SMEs, suggesting that the problem may be much larger in the economy than our model predicts. For policy makers, this research confirms the value of knowledge transfer programs to SMEs in the form of technology support. Our research shows that organisations which have dedicated IT support will tend to be more advanced technologically than those that do not. The implication for entrepreneurs is if they can be persuaded that a technological route is beneficial to them, and that suitable support can be provided via KT, then operational efficiency gains could be made. This paper contributes to knowle

Somatic mutation load of estrogen receptor-positive breast tumors predicts overall survival: an analysis of genome sequence data.

Breast cancer is one of the most commonly diagnosed cancers in women. While there are several effective therapies for breast cancer and important single gene prognostic/predictive markers, more than 40,000 women die from this disease every year. The increasing availability of large-scale genomic datasets provides opportunities for identifying factors that influence breast cancer survival in smaller, well-defined subsets. The purpose of this study was to investigate the genomic landscape of various breast cancer subtypes and its potential associations with clinical outcomes. We used statistical analysis of sequence data generated by the Cancer Genome Atlas initiative including somatic mutation load (SML) analysis, Kaplan-Meier survival curves, gene mutational frequency, and mutational enrichment evaluation to study the genomic landscape of breast cancer. We show that ER(+), but not ER(-), tumors with high SML associate with poor overall survival (HR = 2.02). Further, these high mutation load tumors are enriched for coincident mutations in both DNA damage repair and ER signature genes. While it is known that somatic mutations in specific genes affect breast cancer survival, this study is the first to identify that SML may constitute an important global signature for a subset of ER(+) tumors prone to high mortality. Moreover, although somatic mutations in individual DNA damage genes affect clinical outcome, our results indicate that coincident mutations in DNA damage response and signature ER genes may prove more informative for ER(+) breast cancer survival. Next generation sequencing may prove an essential tool for identifying pathways underlying poor outcomes and for tailoring therapeutic strategies

The search for innovators and early adopters of e-collaborative technologies within small and medium sized enterprises in the UK

New product diffusion theory predicts that innovators and early adopters are critical to the success of new innovations. The rate at which enterprises adopt e-Science technologies must therefore rely upon reliable market intelligence so that the critical early stages of adoption are successfully navigated by developers and planners. Failure to understand attitudes towards new technologies can lead to even useful technologies being under-adopted. This paper applies a survey based methodology to develop estimates of demand for web based virtual Collaborative technologies. We show that approximately 76% of the 1029 firms that we interviewed are technologically ready to deploy these technologies. We also show that 10% of all firms are ready look at these technologies as solutions to collaborative problem solving

Optical observations of the AMPTE artificial comet and magnetotail barium releases

The first AMPTE artificial comet was observed with a low light level television camera operated aboard the NASA CV990 flying out of Moffett Field, California. The comet head, neutral cloud, and comet tail were all observed for four minutes with an unifiltered camera. Brief observations at T + 4 minutes through a 4554A Ba(+) filter confirmed the identification of the structures. The ion cloud expanded along with the neutral cloud at a rate of 2.3 km/sec (diameter) until it reached a final diameter of approx. 170 km at approx. T + 90 s. It also drifted with the neutral cloud until approx. 165 s. By T + 190 s it had reached a steady state velocity of 5.4 km/sec southward. A barium release in the magnetotail was observed from the CV990 in California, Eagle, Alaska, and Fairbanks, Alaska. Over a twenty-five minute period, the center of the barium streak drifted southward (approx. 500 m/sec), upward (24 km/sec) and eastward (approx 1 km/sec) in a nonrotating reference frame. An all-sky TV at Eagle showed a single auroral arc in the far North during this period